CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017777
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sulfite oxidase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Suox 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
88ESPRMYSKEDVRSHNacetylation[1]
88ESPRMYSKEDVRSHNsuccinylation[1]
253LSLDDLHKFPKHEVTubiquitination[2]
280MSKVKEVKGLEWRTGacetylation[3, 4, 5]
280MSKVKEVKGLEWRTGubiquitination[2]
503AQVPAEQKELNIICKacetylation[3, 5]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
 DOMAIN 83 162 Cytochrome b5 heme-binding.
 REGION 166 175 Hinge (By similarity).
 REGION 176 402 Moco domain (By similarity).
 REGION 216 220 Molybdopterin-binding (By similarity).
 REGION 378 380 Molybdopterin-binding (By similarity).
 REGION 403 539 Homodimerization (By similarity).
 METAL 119 119 Iron (heme axial ligand) (By similarity).
 METAL 144 144 Iron (heme axial ligand) (By similarity).
 METAL 265 265 Molybdenum (By similarity).
 BINDING 323 323 Molybdopterin (By similarity).
 BINDING 362 362 Molybdopterin (By similarity).
 BINDING 367 367 Molybdopterin (By similarity).
 MOD_RES 286 286 Phosphothreonine.  
Keyword
 Complete proteome; Heme; Iron; Metal-binding; Mitochondrion; Molybdenum; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MLLQLYRSVV VRLPQAIRVK STPLRLCIQA CSTNDSLEPQ HPSLTFSDDN SRTRRWKVMG 60
TLLGLGVVLV YHEHRCRASQ ESPRMYSKED VRSHNNPKTG VWVTLGSEVF DVTKFVDLHP 120
GGPSKLMLAA GGPLEPFWAL YAVHNQPHVR ELLAEYKIGE LNPEDSMSPS VEASDPYADD 180
PIRHPALRIN SQRPFNAEPP PELLTEGYIT PNPIFFTRNH LPVPNLDPHT YRLHVVGAPG 240
GQSLSLSLDD LHKFPKHEVT VTLQCAGNRR SEMSKVKEVK GLEWRTGAIS TARWAGARLC 300
DVLAQAGHRL CDSEAHVCFE GLDSDPTGTA YGASIPLARA MDPEAEVLLA YEMNGQPLPR 360
DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD YKGFSPSVDW DTVNFDLAPS 420
IQELPIQSAI TQPQDGAIVE SGEVTIKGYA WSGGGRAVIR VDVSVDGGLT WQEAELEGEE 480
QCPRKAWAWR IWQLKAQVPA EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV 540
HVQVVP 546 
Gene Ontology
 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0030151; F:molybdenum ion binding; IEA:InterPro.
 GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
 GO:0008482; F:sulfite oxidase activity; IEA:EC.
 GO:0006790; P:sulfur compound metabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR018506; Cyt_B5_heme-BS.
 IPR014756; Ig_E-set.
 IPR005066; MoCF_OxRdtse_dimer.
 IPR008335; Mopterin_OxRdtase_euk.
 IPR000572; OxRdtase_Mopterin-bd_dom.
 IPR022407; OxRdtase_Mopterin_BS. 
Pfam
 PF00173; Cyt-b5
 PF03404; Mo-co_dimer
 PF00174; Oxidored_molyb 
SMART
  
PROSITE
 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2
 PS00559; MOLYBDOPTERIN_EUK 
PRINTS
 PR00363; CYTOCHROMEB5.
 PR00407; EUMOPTERIN.