UniProt Accession

 GGPPS_MOUSE; Q9WTN0 

Genbank Protein ID

 AB016044; BC069913 

Genbank Nucleotide ID

 BAA76512.1; AAH69913.1 

Protein Name

 Geranylgeranyl pyrophosphate synthase 

Protein Synonyms/Alias

 GGPP synthase; GGPPSase; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase 

Gene Name

 Ggps1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	YLLQLPGKQVRSKLS	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. 

Sequence Annotation

 METAL 64 64 Magnesium 1 (By similarity).
 METAL 64 64 Magnesium 2 (By similarity).
 METAL 68 68 Magnesium 1 (By similarity).
 METAL 68 68 Magnesium 2 (By similarity).
 METAL 188 188 Magnesium 3 (By similarity).
 BINDING 25 25 Isopentenyl diphosphate (By similarity).
 BINDING 28 28 Isopentenyl diphosphate (By similarity).
 BINDING 57 57 Isopentenyl diphosphate (By similarity).
 BINDING 73 73 Dimethylallyl diphosphate (By
 BINDING 74 74 Isopentenyl diphosphate (By similarity).
 BINDING 151 151 Dimethylallyl diphosphate (By
 BINDING 152 152 Dimethylallyl diphosphate (By
 BINDING 185 185 Dimethylallyl diphosphate (By
 BINDING 202 202 Dimethylallyl diphosphate (By
 BINDING 212 212 Dimethylallyl diphosphate (By  

Keyword

 Complete proteome; Cytoplasm; Isoprene biosynthesis; Magnesium; Metal-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004161; F:dimethylallyltranstransferase activity; IEA:EC.
 GO:0004311; F:farnesyltranstransferase activity; ISS:UniProtKB.
 GO:0004337; F:geranyltranstransferase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0045337; P:farnesyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0033384; P:geranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0033386; P:geranylgeranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006720; P:isoprenoid metabolic process; ISS:UniProtKB. 

Interpro

 IPR000092; Polyprenyl_synt.
 IPR017446; Polyprenyl_synth-rel.
 IPR008949; Terpenoid_synth. 

Pfam

 PF00348; polyprenyl_synt 

SMART

  

PROSITE

 PS00723; POLYPRENYL_SYNTHASE_1
 PS00444; POLYPRENYL_SYNTHASE_2 

PRINTS