UniProt Accession

 CDK20_MACMU; Q5EDC3 

Genbank Protein ID

 AY904368 

Genbank Nucleotide ID

 AAW82350.1 

Protein Name

 Cyclin-dependent kinase 20 

Protein Synonyms/Alias

 CDK-activating kinase p42; CAK-kinase p42; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H 

Gene Name

 CDK20 

Gene Synonyms/Alias

 CCRK; CDCH 

Created Date

 July 27, 2013 

Organism

 Macaca mulatta (Rhesus macaque) 

NCBI Taxa ID

 9544 

Lysine Modification

Position	Peptide	Type	References
22	HGIVFKAKHVETGEI	ubiquitination	[1]
129	NIVHRDLKPANLLIS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). 

Sequence Annotation

 DOMAIN 4 243 Protein kinase.
 NP_BIND 10 18 ATP (By similarity).
 ACT_SITE 127 127 Proton acceptor (By similarity).
 BINDING 33 33 ATP (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Cell cycle; Cell division; Cell projection; Cilium; Complete proteome; Cytoplasm; Developmental protein; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS