CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014499
UniProt Accession
Genbank Protein ID
 L46816 
Genbank Nucleotide ID
Protein Name
 Transcription elongation factor B polypeptide 3 
Protein Synonyms/Alias
 Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110 
Gene Name
 Tceb3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
761KIAPMMAKTIKAFKNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). 
Sequence Annotation
 DOMAIN 4 79 TFIIS N-terminal.
 DOMAIN 565 609 F-box.
 REGION 521 680 Activation domain.
 REGION 549 558 Interacting with Elongin BC complex.
 MOD_RES 195 195 Phosphoserine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).
 MOD_RES 380 380 Phosphoserine (By similarity).
 MOD_RES 383 383 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 773 AA 
Protein Sequence
MAAESALQVV EKLQARLAAN PDPKKLLKYL KKLSVLPITV DILVETGVGK TVNSFRKHEQ 60
VGNFARDLVA QWKKLVPVER NNEAEDQDFE KSNSRKRPRD VPQQEEEAEG NYQESWQASG 120
SQPYSPEHRQ KKHRKLPELE RPHKVAHGHE RRDERKRCHK VSPPYSSDPE SSDYGHVQSP 180
PPSSPHQMYT DLSRSPEMDQ EPIVSHPKPG KVHSNTFQDR LGVSHLGEHQ GKGAVSQNKP 240
HKSSHKEKRP VDARGDEKSS VMGREKSHKA SSKEESRRLL SEDSAKEKLP SSVVKKEKDR 300
EGNSLKKKLS PALDVASDNH FKKPKHKDSE KIKSDKNKQS VDSVDSGRGT GDPLPRAKDK 360
VPNNLKAQEG KVRTNSDRKS PGSLPKVEEM DMDDEFEQPT MSFESYLSYD QPRKKKKKVV 420
KTSGTALGEK GLKKKDSKST SKNLNSAQKL PKANENKSDK LQPAGAEPTR PRKVPTDVLP 480
ALPDIPLPAI QTNYRPLPSL ELISSFQPKR KAFSSPQEEE EAGFTGRRMN SKMQVYSGSK 540
CAYLPKMMTL HQQCIRVLKN NIDSIFEVGG VPYSVLEPVL ERCTPDQLYR IEECNHVLIE 600
ETDQLWKVHC HRDFKEERPE EYESWREMYL RLQDAREQRL RLLTNNIRSA HANKPKGRQA 660
KMAFVNSVAK PPRDVRRRQE KFGTGGAAVP EKVRIKPAPY TTGSSHVPAS NSSSSFHSSP 720
EELAYEGPST SSAHLAPVAS SSVSYDPRKP AVKKIAPMMA KTIKAFKNRF SRR 773 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0008023; C:transcription elongation factor complex; IDA:UniProtKB.
 GO:0003690; F:double-stranded DNA binding; TAS:RGD.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:UniProtKB. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR010684; RNA_pol_II_trans_fac_SIII_A.
 IPR003617; TFIIS/CRSP70_N_sub.
 IPR017923; TFIIS_N. 
Pfam
 PF06881; Elongin_A
 PF08711; Med26 
SMART
 SM00509; TFS2N 
PROSITE
 PS50181; FBOX
 PS51319; TFIIS_N 
PRINTS