| Tag | Content |
|---|
| CPLM ID | CPLM-016105 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rabenosyn-5 |
Protein Synonyms/Alias | FYVE finger-containing Rab5 effector protein rabenosyn-5; Zinc finger FYVE domain-containing protein 20 |
Gene Name | Zfyve20 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 276 | EHTPDIVKLYEKLRL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (By similarity). |
Sequence Annotation | REPEAT 495 514 UIM.
ZN_FING 14 37 C2H2-type.
ZN_FING 156 259 FYVE-type.
REGION 99 262 Necessary for the correct targeting to
REGION 263 783 Necessary for the interaction with EHD1
REGION 263 499 Necessary for the interaction with RAB4A
REGION 627 783 Necessary for the interaction with RAB5A |
Keyword | Cell membrane; Coiled coil; Complete proteome; Endosome; Lipoprotein; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 783 AA |
Protein Sequence | MASLDDPGEV REGFLCPLCL KDLQSFYQLQ SHYEEEHLED RDVKGQIKNL VQKARKAKNK 60
LLKREGDDRV EPGTQGYESF SYGGVDPYMW EPQELGAMRS HLSDFKKHRA ARIDHYVVEV 120
NKLIIRLEKL TAFDRTNTET SKIRAIEKSV VPWVNDQDVP FCPDCGNKFS IRNRRHHCRL 180
CGSIMCKKCM ELIGLPLAHK LTSASKDSLS THTSPSQSPN SVHGSRRGSI SSMSSVSSVL 240
DEKDDDRIRC CTHCKDKLLK REQQMDEKEH TPDIVKLYEK LRLCMEKVDQ KAPEYIRMAA 300
SLNAGETTYN LEHANDLRVE VQKVYELIDA LSKKILTLGL NQDPSPHPNT LRLQRMIRYS 360
ATLFVQEKLL GLMSLPTKEQ FEELKKKRKQ DLEQKRTVER QAALESRRKL EERQSGLASH 420
TANGDVRSLR GIPPPLRKAE GWLPLSEGQG QSEDPDPLLQ QIYNITSFIR QAKAAGRTDE 480
VRTLQENLRQ LQDEYDQQQT EKAIELSRKQ AEEEELQREQ LQMLRKRELE REQEQFLAAS 540
LQTRTRVLEL REVIPFQLEA SRGPHIDLSY SLDQDSSPVQ SSTAPDILTP GSALAPMHLW 600
SGPPALGQET LPQSTMSQQS DKASLNPFDE DDLSSPTEGA ISPAAVEAFL GPPAAVTKEY 660
NPFEEDAEEE EVAELGAGNP FTDPDSPAPN PFDEDDGPRP ASPAAPGNPF EECPSTNPFE 720
VDSDSGMEAE EHIEEELLLQ QIDNIKAYIF DAKQCGRMDE VEVLTENLRE LKCTLAKQKG 780
APN 783 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |