CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017637
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Maestro heat-like repeat-containing protein family member 1 
Protein Synonyms/Alias
 HEAT repeat-containing protein 7A 
Gene Name
 MROH1 
Gene Synonyms/Alias
 HEATR7A; KIAA1833 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98LASSEMTKTKDLVWDubiquitination[1]
276GILALYKKHAETFYLubiquitination[2]
514SLVHLAQKRQEAGADubiquitination[2]
645YDEAPQEKNFLYKCIubiquitination[2]
650QEKNFLYKCIGTTLGubiquitination[2]
662TLGAASSKEVVRKHLubiquitination[2]
667SSKEVVRKHLQELLEubiquitination[2]
717VRSEVFRKSIGILNIubiquitination[2, 3, 4]
726IGILNIFKDRSENEVubiquitination[1]
759PRELVLAKVESDILRubiquitination[1, 2]
817GSFHFTRKAELVAQMubiquitination[2]
929EHLSPWIKSPRGHERubiquitination[2]
1020AERLLSLKDGLVHPDubiquitination[2]
1091RGGVLQEKVPEIVSVubiquitination[1, 2]
1177MSRDVPFKESRAFLLubiquitination[1, 2]
1397LASGCPDKVRTHGPQubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
 REPEAT 3 41 HEAT 1.
 REPEAT 159 198 HEAT 2.
 REPEAT 344 382 HEAT 3.
 REPEAT 385 423 HEAT 4.
 REPEAT 1048 1086 HEAT 5.
 REPEAT 1358 1396 HEAT 6.
 REPEAT 1605 1641 HEAT 7.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1641 AA 
Protein Sequence
MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 60
YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 120
FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 180
VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 240
LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 300
TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 360
SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH 420
GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM 480
SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT 540
GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ 600
EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS 660
SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG 720
ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKVLGIK 780
VETKDPALKL CLVQSVCMVS RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI 840
RKKAMLTCTY LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL 900
EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF LEHLRVSALV 960
PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG YEGFSRDYRD DVAERLLSLK 1020
DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ LISLLLTMFE ALGDPEKNCS RAATVMINCL 1080
LQERGGVLQE KVPEIVSVLR SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP 1140
LDSHTCMLWR ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT 1200
CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG ASPALATRNL 1260
EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG HEEGATRLAR AMAEHAGPRL 1320
PLVLKTLACT HSSAYENQRV TTTAFLAELL NSNVANDLML LDSLLESLAA RQKDTCASVR 1380
RLVLRGLANL ASGCPDKVRT HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES 1440
WDLRSGLLHV AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL 1500
LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL NTTCKHLMHH 1560
FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP RQQPQVDLDQ LIAALQILLK 1620
DPAPEVRTRA AEALGRLVKL A 1641 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS