CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038872
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Idh3a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
58MKIFDAAKAPIQWEEacetylation[1]
77AIQGPGGKWMIPPEAacetylation[1]
85WMIPPEAKESMDKNKacetylation[1]
92KESMDKNKMGLKGPLacetylation[1]
96DKNKMGLKGPLKTPIacetylation[1]
100MGLKGPLKTPIAAGHacetylation[1]
177LITEGASKRIAEFAFacetylation[1]
200SNVTAVHKANIMRMSacetylation[1]
223REVAENCKDIKFNEMacetylation[1]
336AACFATIKDGKSLTKacetylation[1]
339FATIKDGKSLTKDLGacetylation[1]
343KDGKSLTKDLGGNSKacetylation[1]
350KDLGGNSKCSDFTEEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MAGSAWVSKV SRLLGAFHNT KQVTRGFAGG VQTVTLIPGD GIGPEISASV MKIFDAAKAP 60
IQWEERNVTA IQGPGGKWMI PPEAKESMDK NKMGLKGPLK TPIAAGHPSM NLLLRKTFDL 120
YANVRPCVSI EGYKTPYTDV NIVTIRENTE GEYSGIEHVI VDGVVQSIKL ITEGASKRIA 180
EFAFEYARNN HRSNVTAVHK ANIMRMSDGL FLQKCREVAE NCKDIKFNEM YLDTVCLNMV 240
QDPSQFDVLV MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD 300
MANPTALLLS AVMMLRHMGL FDHAAKIEAA CFATIKDGKS LTKDLGGNSK CSDFTEEICR 360
RVKDLD 366 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004434; Isocitrate_DH_NAD.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS