CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diphthamide biosynthesis protein 2 
Protein Synonyms/Alias
 cDNA FLJ55730, highly similar to Homo sapiens DPH2 homolog (DPH2), transcript variant 1, mRNA 
Gene Name
 DPH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88AFYVGGSKASPDPDLubiquitination[1, 2, 3]
121SCCPDTGKTQDEGARubiquitination[2, 3, 4]
177NLTQAAGKRSYVLALubiquitination[2]
289LRPPPAWKSSNDHGSubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MLWLWLHDWR RRQGQRCSFW VTQPTAEALA TLLRPRYLDL LVSSPAFPQP VGSLSPEPMP 60
LERFGRRFPL APGRRLEEYG AFYVGGSKAS PDPDLDPDLS RLLLGWAPGQ PFSSCCPDTG 120
KTQDEGARAG RLRARRRYLV ERARDARVVG LLAGTLGVAQ HREALAHLRN LTQAAGKRSY 180
VLALGRPTPA KLANFPEVDV FVLLACPLGA LAPQLSGSFF QPILAPCELE AACNPAWPPP 240
GLAPHLTHYA DLLPGSPFHV ALPPPESELW ETPDVSLITG DLRPPPAWKS SNDHGSLALT 300
PRPQLELAES SPAASFLSSR SWQGLEPRLG QTPVTEAVSG RRGIAIAYED EGSG 354 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0017183; P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine; IEA:InterPro. 
Interpro
 IPR010014; DHP2_eu.
 IPR002728; DPH1/DPH2. 
Pfam
 PF01866; Diphthamide_syn 
SMART
  
PROSITE
  
PRINTS