| Tag | Content |
|---|
| CPLM ID | CPLM-015861 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial Rho GTPase 2 |
Protein Synonyms/Alias | MIRO-2; Ras homolog gene family member T2 |
Gene Name | Rhot2 |
Gene Synonyms/Alias | Arht2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 453 | RDRDAPEKLPTHTIN | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). |
Sequence Annotation | DOMAIN 1 177 Miro 1.
DOMAIN 184 219 EF-hand 1.
DOMAIN 304 339 EF-hand 2.
DOMAIN 411 622 Miro 2.
NP_BIND 11 18 GTP 1 (Potential).
NP_BIND 57 61 GTP 1 (Potential).
NP_BIND 118 121 GTP 1 (Potential).
NP_BIND 424 431 GTP 2 (Potential).
NP_BIND 463 467 GTP 2 (Potential).
NP_BIND 528 531 GTP 2 (Potential). |
Keyword | Calcium; Complete proteome; GTP-binding; Hydrolase; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 622 AA |
Protein Sequence | MRRDVRILLL GEAQVGKTSL ILSLVGEEFP EEVPARAEEI TIPADVTPEK VPTHIVDYSE 60
AEQTEEELQE EIHKANVVCV VYDVSEEATI EKIRTKWIPL VNGRTATGPR LPIILVGNKS 120
DLRPGSTIEA VLPIMSQFPE IETCVECSAK HLRNISELFY YAQKAVLHPT APLYDPEAKQ 180
LRPACAQALT RIFRLSDQDL DHALSDKELN AFQKSCFGHP LAPQALEDVK RVVCKNVAGG 240
VQDDRLTLEG FLFLNTLFIQ RGRHETTWTI LRRFGYSDSL ELTPDYLCPP LYVPPGCSTE 300
LNHRGYQFVQ RVFEKHDQDH DGVLSPTELE SLFSVFSVAP WGPELLHTVP TEAGCLSLRG 360
YLCQWTLVTY LDVQHCLAHL GYLGYPTLCE QDSQAQAITV TREKRLDQEK GQTQRSVLMC 420
KVLGARGVGK SAFLQAFLGH SLGEARDRDA PEKLPTHTIN TVRVSGQEKY LILCEVNADS 480
LLDTSLDTTC DVACLMFDSS DPETFVQCAT IYKRYYMDGQ TPCLFISSKA DLPEGVAPPG 540
LSPAEFCRRH RLPAPASFSC LGPAQSSIDV FTQLATMATF PHLAHTELHP TPFWLRGVLV 600
AVGTAVAAVL SFSLYRVLVK SR 622 |
Gene Ontology | GO:0031307; C:integral to mitochondrial outer membrane; ISS:UniProtKB. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0019725; P:cellular homeostasis; ISS:UniProtKB. GO:0006184; P:GTP catabolic process; IEA:GOC. GO:0097345; P:mitochondrial outer membrane permeabilization; ISS:UniProtKB. GO:0047497; P:mitochondrion transport along microtubule; ISS:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |