CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027643
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoplasmic aconitase 
Protein Synonyms/Alias
  
Gene Name
 Aco1 
Gene Synonyms/Alias
 aco1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2******MKNPFAHLAubiquitination[1]
19LDAAQPGKRFFNLNKubiquitination[1]
26KRFFNLNKLEDSRYGubiquitination[1]
56NCDEFLVKKNDIENIubiquitination[1]
79KNIEVPFKPARVILQubiquitination[1]
141RRADSLQKNQDLEFEubiquitination[1]
389GPKRPQDKVAVSEMKubiquitination[1]
406FESCLGAKQGFKGFQubiquitination[1]
465GAGLLAKKAVEAGLSacetylation[2]
465GAGLLAKKAVEAGLSubiquitination[1]
474VEAGLSVKPYIKTSLubiquitination[1]
582TVRIDFEKEPLGVNAubiquitination[1]
620HVIPGMFKEVYQKIEubiquitination[1]
625MFKEVYQKIETVNKSacetylation[2]
625MFKEVYQKIETVNKSubiquitination[1]
631QKIETVNKSWNALAAubiquitination[1]
642ALAAPSEKLYAWNPKubiquitination[1]
649KLYAWNPKSTYIKSPubiquitination[1]
654NPKSTYIKSPPFFESubiquitination[1]
742ANIRLLNKFLNKQAPubiquitination[1]
746LLNKFLNKQAPQTVHubiquitination[1]
782PLIVLAGKEYGSGSSubiquitination[1]
795SSRDWAAKGPFLLGIubiquitination[1]
854INIPEDLKPRMTVQIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 899 AA 
Protein Sequence
MKNPFAHLAE PLDAAQPGKR FFNLNKLEDS RYGRLPFSIR VLLEAAVRNC DEFLVKKNDI 60
ENILNWNVMQ HKNIEVPFKP ARVILQDFTG VPAVVDFAAM RDAVKKLGGN PEKINPVCPA 120
DLVIDHSIQV DFNRRADSLQ KNQDLEFERN KERFEFLKWG SQAFCNMRII PPGSGIIHQV 180
NLEYLARVVF DQDGCYYPDS LVGTDSHTTM IDGLGVLGWE AFPCSAVTAG VGGIEAEAVM 240
LGQPISMVLP QVIGYKLMGK PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI 300
ADRATIANMC PEYGATAAFF PVDEVSIAYL LQTGREEDKV KHIQKYLQAV GMFRDFNDTS 360
QDPDFTQVVE LDLKTVVPCC SGPKRPQDKV AVSEMKKDFE SCLGAKQGFK GFQVAPDRHN 420
DRKTFLYSNS EFTLAHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVEAG LSVKPYIKTS 480
LSPGSGVVTY YLRESGVMPY LSQLGFDVVG YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG 540
VLSGNRNFEG RVHPNTRANY LASPPLVIAY AIAGTVRIDF EKEPLGVNAQ GRQVFLKDIW 600
PTRDEIQAVE RQHVIPGMFK EVYQKIETVN KSWNALAAPS EKLYAWNPKS TYIKSPPFFE 660
SLTLDLQPPK SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG LTPREFNSYG 720
SRRGNDAIMA RGTFANIRLL NKFLNKQAPQ TVHLPSGETL DVFDAAERYQ QAGLPLIVLA 780
GKEYGSGSSR DWAAKGPFLL GIKAVLAESY ERIHRSNLVG MGVIPLEYLP GETADSLGLT 840
GRERYTINIP EDLKPRMTVQ IKLDTGKTFQ AVMRFDTDVE LTYFHNGGIL NYMIRKMAQ 899 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0003994; F:aconitate hydratase activity; IEA:Compara.
 GO:0030350; F:iron-responsive element binding; IEA:Compara.
 GO:0006101; P:citrate metabolic process; IEA:Compara.
 GO:0010040; P:response to iron(II) ion; IEA:Compara. 
Interpro
 IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
 IPR015937; Acoase/IPM_deHydtase.
 IPR001030; Acoase/IPM_deHydtase_lsu_aba.
 IPR015928; Aconitase/3IPM_dehydase_swvl.
 IPR006249; Aconitase/Fe_reg_prot_2.
 IPR015934; Aconitase/Fe_reg_prot_2/AcnD.
 IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
 IPR018136; Aconitase_4Fe-4S_BS.
 IPR000573; AconitaseA/IPMdHydase_ssu_swvl. 
Pfam
 PF00330; Aconitase
 PF00694; Aconitase_C 
SMART
  
PROSITE
 PS00450; ACONITASE_1
 PS01244; ACONITASE_2 
PRINTS
 PR00415; ACONITASE.