UniProt Accession

 PRS33_HUMAN; Q8NF86; A6NNQ3; Q8N171 

Genbank Protein ID

 AF536382; AC092117; CH471112; BC036846; BC062334 

Genbank Nucleotide ID

 AAN04055.1; EAW85469.1; AAH36846.2; AAH62334.1 

Protein Name

 Serine protease 33 

Protein Synonyms/Alias

 Serine protease EOS 

Gene Name

 PRSS33 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	AAGTQGRKSAACGQP	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. 

Sequence Annotation

 DOMAIN 37 279 Peptidase S1.
 ACT_SITE 77 77 Charge relay system (By similarity).
 ACT_SITE 126 126 Charge relay system (By similarity).
 ACT_SITE 231 231 Charge relay system (By similarity).
 DISULFID 62 78 By similarity.
 DISULFID 160 237 By similarity.
 DISULFID 193 216 By similarity.
 DISULFID 227 255 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Hydrolase; Protease; Reference proteome; Secreted; Serine protease; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 280 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR009003; Trypsin-like_Pept_dom. 

Pfam

 PF00089; Trypsin 

SMART

 SM00020; Tryp_SPc 

PROSITE

 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 

PRINTS

 PR00722; CHYMOTRYPSIN.