CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021652
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 532 
Protein Synonyms/Alias
  
Gene Name
 ZNF532 
Gene Synonyms/Alias
 KIAA1629 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
175APQQDYDKLKALGGEacetylation[1]
248DGKLSSEKNDTSLPSubiquitination[2]
1167TQPLKKLKINVFKVHubiquitination[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 616 635 C2H2-type 1; degenerate.
 ZN_FING 754 779 C2H2-type 2; degenerate.
 ZN_FING 783 805 C2H2-type 3.
 ZN_FING 842 865 C2H2-type 4.
 ZN_FING 870 893 C2H2-type 5.
 ZN_FING 905 927 C2H2-type 6.
 ZN_FING 936 959 C2H2-type 7.
 ZN_FING 1025 1048 C2H2-type 8.
 ZN_FING 1055 1078 C2H2-type 9.
 ZN_FING 1085 1111 C2H2-type 10; degenerate.
 ZN_FING 1203 1226 C2H2-type 11.
 ZN_FING 1264 1286 C2H2-type 12.
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 134 134 Phosphoserine.
 MOD_RES 205 205 Phosphothreonine.
 MOD_RES 252 252 Phosphoserine.
 MOD_RES 307 307 Phosphoserine.
 MOD_RES 314 314 Phosphoserine.
 MOD_RES 434 434 Phosphoserine.
 MOD_RES 1140 1140 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1301 AA 
Protein Sequence
MTMGDMKTPD FDDLLAAFDI PDMVDPKAAI ESGHDDHESH MKQNAHGEDD SHAPSSSDVG 60
VSVIVKNVRN IDSSEGGEKD GHNPTGNGLH NGFLTASSLD SYSKDGAKSL KGDVPASEVT 120
LKDSTFSQFS PISSAEEFDD DEKIEVDDPP DKEDMRSSFR SNVLTGSAPQ QDYDKLKALG 180
GENSSKTGLS TSGNVEKNKA VKRETEASSI NLSVYEPFKV RKAEDKLKES SDKVLENRVL 240
DGKLSSEKND TSLPSVAPSK TKSSSKLSSC IAAIAALSAK KAASDSCKEP VANSRESSPL 300
PKEVNDSPRA ADKSPESQNL IDGTKKPSLK QPDSPRSISS ENSSKGSPSS PAGSTPAIPK 360
VRIKTIKTSS GEIKRTVTRV LPEVDLDSGK KPSEQTASVM ASVTSLLSSP ASAAVLSSPP 420
RAPLQSAVVT NAVSPAELTP KQVTIKPVAT AFLPVSAVKT AGSQVINLKL ANNTTVKATV 480
ISAASVQSAS SAIIKAANAI QQQTVVVPAS SLANAKLVPK TVHLANLNLL PQGAQATSEL 540
RQVLTKPQQQ IKQAIINAAA SQPPKKVSRV QVVSSLQSSV VEAFNKVLSS VNPVPVYIPN 600
LSPPANAGIT LPTRGYKCLE CGDSFALEKS LTQHYDRRSV RIEVTCNHCT KNLVFYNKCS 660
LLSHARGHKE KGVVMQCSHL ILKPVPADQM IVSPSSNTST STSTLQSPVG AGTHTVTKIQ 720
SGITGTVISA PSSTPITPAM PLDEDPSKLC RHSLKCLECN EVFQDETSLA THFQQAADTS 780
GQKTCTICQM LLPNQCSYAS HQRIHQHKSP YTCPECGAIC RSVHFQTHVT KNCLHYTRRV 840
GFRCVHCNVV YSDVAALKSH IQGSHCEVFY KCPICPMAFK SAPSTHSHAY TQHPGIKIGE 900
PKIIYKCSMC DTVFTLQTLL YRHFDQHIEN QKVSVFKCPD CSLLYAQKQL MMDHIKSMHG 960
TLKSIEGPPN LGINLPLSIK PATQNSANQN KEDTKSMNGK EKLEKKSPSP VKKSMETKKV 1020
ASPGWTCWEC DCLFMQRDVY ISHVRKEHGK QMKKHPCRQC DKSFSSSHSL CRHNRIKHKG 1080
IRKVYACSHC PDSRRTFTKR LMLEKHVQLM HGIKDPDLKE MTDATNEEET EIKEDTKVPS 1140
PKRKLEEPVL EFRPPRGAIT QPLKKLKINV FKVHKCAVCG FTTENLLQFH EHIPQHKSDG 1200
SSYQCRECGL CYTSHVSLSR HLFIVHKLKE PQPVSKQNGA GEDNQQENKP SHEDESPDGA 1260
VSDRKCKVCA KTFETEAALN THMRTHGMAF IKSKRMSSAE K 1301 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS