CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000452
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Monocarboxylate transporter 7 
Protein Synonyms/Alias
 MCT 7; Monocarboxylate transporter 6; MCT 6; Solute carrier family 16 member 6 
Gene Name
 SLC16A6 
Gene Synonyms/Alias
 MCT6; MCT7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
220IVIQENRKEAQYMLEacetylation[1]
220IVIQENRKEAQYMLEubiquitination[2]
230QYMLENEKTRTSIDSubiquitination[2]
249VELTTSPKNVPTHTNubiquitination[2]
271DMQQVLVKTSPRPSEubiquitination[2]
495KVVSHRGKTLQDIPEubiquitination[2]
511FLEMDLAKNEHRVHVubiquitination[2]
Reference
 [1] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). 
Sequence Annotation
 MOD_RES 234 234 Phosphoserine (By similarity).
 MOD_RES 237 237 Phosphoserine.
 MOD_RES 240 240 Phosphoserine.
 MOD_RES 247 247 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN DLMDSFNESN 60
SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL VSTGMVAASF SQEVSHMYVA 120
IGIISGLGYC FSFLPTVTIL SQYFGKRRSI VTAVASTGEC FAVFAFAPAI MALKERIGWR 180
YSLLFVGLLQ LNIVIFGALL RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS 240
GVELTTSPKN VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF 300
GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV LNREPIRKIY 360
IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG GTHIPLLAED DVVGIEKMSS 420
AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ 480
HHHSGETKVV SHRGKTLQDI PEDFLEMDLA KNEHRVHVQM EPV 523 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0008028; F:monocarboxylic acid transmembrane transporter activity; TAS:ProtInc.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS