CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ78114, highly similar to Homo sapiens thymidylate synthetase, mRNA 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104NAKELSSKGVKIWDAubiquitination[1]
107ELSSKGVKIWDANGSubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Methyltransferase; Nucleotide biosynthesis; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 313 AA 
Protein Sequence
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG 60
MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS 120
LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC 180
AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSRDMG LGVPFNIASY ALLTYMIAHI 240
TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG 300
YNPHPTIKME MAV 313 
Gene Ontology
 GO:0004799; F:thymidylate synthase activity; IEA:InterPro.
 GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
 GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR023451; Thymidate_synth/dCMP_Mease.
 IPR000398; Thymidylate_synthase.
 IPR020940; Thymidylate_synthase_AS. 
Pfam
 PF00303; Thymidylat_synt 
SMART
  
PROSITE
 PS00091; THYMIDYLATE_SYNTHASE 
PRINTS
 PR00108; THYMDSNTHASE.