CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023148
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Long-chain-fatty-acid--CoA ligase 5 
Protein Synonyms/Alias
 Long-chain acyl-CoA synthetase 5; LACS 5 
Gene Name
 ACSL5 
Gene Synonyms/Alias
 ACS5; FACL5; UNQ633/PRO1250 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256VLIGNVEKGFTPSLKubiquitination[1]
276DPFDDDLKQRGEKSGubiquitination[1]
281DLKQRGEKSGIEILSubiquitination[1]
297YDAENLGKEHFRKPVubiquitination[1]
397RLLADDMKTLKPTLFubiquitination[1]
400ADDMKTLKPTLFPAVubiquitination[1]
417LLNRIYDKVQNEAKTubiquitination[1]
460WDKLIFAKIQDSLGGubiquitination[1]
562NVFKGYLKDPEKTQEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. 
Sequence Annotation
  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Endoplasmic reticulum; Fatty acid metabolism; Ligase; Lipid metabolism; Magnesium; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 683 AA 
Protein Sequence
MDALKPPCLW RNHERGKKDR DSCGRKNSEP GSPHSLEALR DAAPSQGLNF LLLFTKMLFI 60
FNFLFSPLPT PALICILTFG AAIFLWLITR PQPVLPLLDL NNQSVGIEGG ARKGVSQKNN 120
DLTSCCFSDA KTMYEVFQRG LAVSDNGPCL GYRKPNQPYR WLSYKQVSDR AEYLGSCLLH 180
KGYKSSPDQF VGIFAQNRPE WIISELACYT YSMVAVPLYD TLGPEAIVHI VNKADIAMVI 240
CDTPQKALVL IGNVEKGFTP SLKVIILMDP FDDDLKQRGE KSGIEILSLY DAENLGKEHF 300
RKPVPPSPED LSVICFTSGT TGDPKGAMIT HQNIVSNAAA FLKCVEHAYE PTPDDVAISY 360
LPLAHMFERI VQAVVYSCGA RVGFFQGDIR LLADDMKTLK PTLFPAVPRL LNRIYDKVQN 420
EAKTPLKKFL LKLAVSSKFK ELQKGIIRHD SFWDKLIFAK IQDSLGGRVR VIVTGAAPMS 480
TSVMTFFRAA MGCQVYEAYG QTECTGGCTF TLPGDWTSGH VGVPLACNYV KLEDVADMNY 540
FTVNNEGEVC IKGTNVFKGY LKDPEKTQEA LDSDGWLHTG DIGRWLPNGT LKIIDRKKNI 600
FKLAQGEYIA PEKIENIYNR SQPVLQIFVH GESLRSSLVG VVVPDTDVLP SFAAKLGVKG 660
SFEELCQNQV VREAILEDLQ KIGKESGLKT FEQVKAIFLH PEPFSIENGL LTPTLKAKRG 720
ELSKYFRTQI DSLYEHIQD 739 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:UniProtKB.
 GO:0001676; P:long-chain fatty acid metabolic process; IEA:GOC.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IDA:UniProtKB.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS