| Tag | Content |
|---|
| CPLM ID | CPLM-012907 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coproporphyrinogen-III oxidase, mitochondrial |
Protein Synonyms/Alias | COX; Coprogen oxidase; Coproporphyrinogenase |
Gene Name | Cpox |
Gene Synonyms/Alias | Cpo |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 393 | LVYDRGTKFGLFTPG | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity). |
Sequence Annotation | REGION 182 191 Important for dimerization (By
REGION 249 251 Substrate binding (By similarity).
REGION 381 417 Important for dimerization (By
REGION 400 405 Substrate binding (By similarity).
ACT_SITE 247 247 Proton donor (By similarity).
BINDING 233 233 Substrate (By similarity).
MOD_RES 99 99 Phosphoserine (By similarity).
MOD_RES 360 360 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Heme biosynthesis; Mitochondrion; Oxidoreductase; Phosphoprotein; Porphyrin biosynthesis; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 443 AA |
Protein Sequence | MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG 60
SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM 120
SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT 180
CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN 240
PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 300
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 360
HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 420
SPPENSKEAE ILEVLRHPKD WVH 443 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; IDA:RGD. GO:0005758; C:mitochondrial intermembrane space; IDA:RGD. GO:0004109; F:coproporphyrinogen oxidase activity; IDA:RGD. GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. GO:0006782; P:protoporphyrinogen IX biosynthetic process; IDA:RGD. GO:0046685; P:response to arsenic-containing substance; IEP:RGD. GO:0017085; P:response to insecticide; IEP:RGD. GO:0010039; P:response to iron ion; IEP:RGD. GO:0010288; P:response to lead ion; IEP:RGD. GO:0051597; P:response to methylmercury; IEP:RGD. |
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