UniProt Accession

 B4DI29_HUMAN; B4DI29 

Genbank Protein ID

 AC078819; AK295387 

Genbank Nucleotide ID

 BAG58341.1 

Protein Name

 G/T mismatch-specific thymine DNA glycosylase 

Protein Synonyms/Alias

 cDNA FLJ60553, highly similar to G/T mismatch-specific thymine DNA glycosylase(EC 3.2.2.-) 

Gene Name

 TDG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	SKEVFGVKVKNLEFG	ubiquitination	[1]
44	EVFGVKVKNLEFGLQ	ubiquitination	[1]
54	EFGLQPHKIPDTETL	ubiquitination	[1]
81	QFPRAQDKVHYYIKL	ubiquitination	[1]
87	DKVHYYIKLKDLRDQ	ubiquitination	[1]
89	VHYYIKLKDLRDQLK	ubiquitination	[1]
96	KDLRDQLKGIERNMD	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro. 

Interpro

 IPR015637; DNA_glycosylase_G/T-mismatch.
 IPR005122; Uracil-DNA_glycosylase-like. 

Pfam

  

SMART

  

PROSITE

  

PRINTS