| Tag | Content |
|---|
| CPLM ID | CPLM-017142 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Netrin receptor UNC5B |
Protein Synonyms/Alias | Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1 |
Gene Name | UNC5B |
Gene Synonyms/Alias | P53RDL1; UNC5H2; UNQ1883/PRO4326 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 416 | GFHPVNFKTARPSNP | ubiquitination | [1] | | 454 | ALQDSTDKIPMTNSP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. |
Sequence Annotation | DOMAIN 48 145 Ig-like.
DOMAIN 147 242 Ig-like C2-type.
DOMAIN 246 300 TSP type-1 1.
DOMAIN 302 354 TSP type-1 2.
DOMAIN 544 688 ZU5.
DOMAIN 865 943 Death.
REGION 689 838 UPA domain (By similarity).
REGION 707 725 Interaction with DCC (By similarity).
LIPID 403 403 S-palmitoyl cysteine.
CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
DISULFID 69 128 By similarity.
DISULFID 174 225 By similarity.
DISULFID 258 295 By similarity.
DISULFID 262 299 By similarity.
DISULFID 273 285 By similarity. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 945 AA |
Protein Sequence | MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF LQEPQDAYIV 60
KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA TGLRVREVQI EVSRQQVEEL 120
FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV 180
PVAEVEWLKN EDVIDPTQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT 240
VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP 300
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCMQMLEAS 360
GDAALYAGLV VAIFVVVAIL MAVGVVVYRR NCRDFDTDIT DSSAALTGGF HPVNFKTARP 420
SNPQLLHPSV PPDLTASAGI YRGPVYALQD STDKIPMTNS PLLDPLPSLK VKVYSSSTTG 480
SGPGLADGAD LLGVLPPGTY PSDFARDTHF LHLRSASLGS QQLLGLPRDP GSSVSGTFGC 540
LGGRLSIPGT GVSLLVPNGA IPQGKFYEMY LLINKAESTL PLSEGTQTVL SPSVTCGPTG 600
LLLCRPVILT MPHCAEVSAR DWIFQLKTQA HQGHWEEVVT LDEETLNTPC YCQLEPRACH 660
ILLDQLGTYV FTGESYSRSA VKRLQLAVFA PALCTSLEYS LRVYCLEDTP VALKEVLELE 720
RTLGGYLVEE PKPLMFKDSY HNLRLSLHDL PHAHWRSKLL AKYQEIPFYH IWSGSQKALH 780
CTFTLERHSL ASTELTCKIC VRQVEGEGQI FQLHTTLAET PAGSLDTLCS APGSTVTTQL 840
GPYAFKIPLS IRQKICNSLD APNSRGNDWR MLAQKLSMDR YLNYFATKAS PTGVILDLWE 900
ALQQDDGDLN SLASALEEMG KSEMLVAVAT DGDC 934 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; TAS:Reactome. GO:0007411; P:axon guidance; TAS:Reactome. GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |