UniProt Accession

 B7ZKK9_HUMAN; B7ZKK9 

Genbank Protein ID

 AL118555; AL132992; AL136038; BC143234 

Genbank Nucleotide ID

 AAI43235.1 

Protein Name

 PPP2R5E protein 

Protein Synonyms/Alias

 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 

Gene Name

 PPP2R5E 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	SQFRSQGKPIELTPL	ubiquitination	[1, 2]
173	EFQPSIAKKYIDQKF	ubiquitination	[1, 3]
209	VLHRIYGKFLGLRAF	ubiquitination	[1]
308	PVIRGLMKFWPKTCS	ubiquitination	[1]
346	KIQEPLFKQIAKCVS	ubiquitination	[1, 2]
444	EREELWKKLEDLELK	methylation	[4]
444	EREELWKKLEDLELK	ubiquitination	[1]
451	KLEDLELKRGLRRDG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 462 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002554; PP2A_B56. 

Pfam

 PF01603; B56 

SMART

  

PROSITE

  

PRINTS