UniProt Accession

 SCN4B_HUMAN; Q8IWT1; E9PPT5; Q6PIG5 

Genbank Protein ID

 AY149967; AP002800; BC035017 

Genbank Nucleotide ID

 AAN74584.1; AAH35017.1 

Protein Name

 Sodium channel subunit beta-4 

Protein Synonyms/Alias

  

Gene Name

 SCN4B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
92	KNEKSDPKVTLKDDD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity). 

Sequence Annotation

 DOMAIN 31 148 Ig-like C2-type.
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).
 CARBOHYD 71 71 N-linked (GlcNAc...) (Potential).
 CARBOHYD 113 113 N-linked (GlcNAc...) (Potential).
 DISULFID 53 131 By similarity.
 DISULFID 58 58 Interchain; with alpha subunit (By  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel; Ion transport; Long QT syndrome; Membrane; Reference proteome; Signal; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0014704; C:intercalated disc; ISS:BHF-UCL.
 GO:0001518; C:voltage-gated sodium channel complex; IDA:UniProtKB.
 GO:0017080; F:sodium channel regulator activity; IDA:BHF-UCL.
 GO:0086006; F:voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential; IMP:BHF-UCL.
 GO:0086067; P:AV node cell to bundle of His cell communication; IMP:BHF-UCL.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0010765; P:positive regulation of sodium ion transport; IDA:BHF-UCL.
 GO:0086002; P:regulation of cardiac muscle cell action potential involved in contraction; IMP:BHF-UCL.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS