UniProt Accession

 ILEU_HUMAN; P30740; A8K5L2; Q53FB9; Q5W0E1; Q9UDF8 

Genbank Protein ID

 M93056; AF053630; AK291327; BT006928; AK223370; AL139092; BC009015 

Genbank Nucleotide ID

 AAC31394.1; BAF84016.1; AAP35574.1; BAD97090.1; CAH73667.1; AAH09015.1 

Protein Name

 Leukocyte elastase inhibitor 

Protein Synonyms/Alias

 LEI; Monocyte/neutrophil elastase inhibitor; EI; M/NEI; Peptidase inhibitor 2; PI-2; Serpin B1 

Gene Name

 SERPINB1 

Gene Synonyms/Alias

 ELANH2; MNEI; PI2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
137	KTINQWVKGQTEGKI	acetylation	[1]
177	NWKDKFMKEATTNAP	acetylation	[1]
177	NWKDKFMKEATTNAP	ubiquitination	[2, 3]
196	KKDRKTVKMMYQKKK	ubiquitination	[2, 3]
301	QDLFNSSKADLSGMS	ubiquitination	[4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 137 137 N6-acetyllysine.
 MOD_RES 177 177 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Protease inhibitor; Reference proteome; Serine protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; NAS:UniProtKB.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR015557; Protease_inhib_serpin_B1.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS