UniProt Accession

 ADHX_DROME; P46415; Q9VGV2 

Genbank Protein ID

 U07799; U07641; AE014297; AY089518; AY089615 

Genbank Nucleotide ID

 AAA57187.1; AAB02520.1; AAF54571.1; AAL90256.1; AAL90353.1 

Protein Name

 Alcohol dehydrogenase class-3 

Protein Synonyms/Alias

 Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; Octanol dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase 

Gene Name

 Fdh 

Gene Synonyms/Alias

 gfd; ODH; CG6598 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
342	KLVEDYLKKDLLVDE	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. 

Sequence Annotation

 METAL 48 48 Zinc 1; catalytic (By similarity).
 METAL 70 70 Zinc 1; catalytic (By similarity).
 METAL 100 100 Zinc 2 (By similarity).
 METAL 103 103 Zinc 2 (By similarity).
 METAL 106 106 Zinc 2 (By similarity).
 METAL 114 114 Zinc 2 (By similarity).
 METAL 177 177 Zinc 1; catalytic (By similarity).
 MOD_RES 2 2 N-acetylserine (Probable).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0004022; F:alcohol dehydrogenase (NAD) activity; IDA:FlyBase.
 GO:0004552; F:octanol dehydrogenase activity; IDA:FlyBase.
 GO:0051903; F:S-(hydroxymethyl)glutathione dehydrogenase activity; IDA:FlyBase.
 GO:0080007; F:S-nitrosoglutathione reductase activity; IMP:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006066; P:alcohol metabolic process; IC:FlyBase.
 GO:0006069; P:ethanol oxidation; IEA:InterPro.
 GO:0080164; P:regulation of nitric oxide metabolic process; IC:FlyBase.
 GO:2000169; P:regulation of peptidyl-cysteine S-nitrosylation; IMP:FlyBase.
 GO:0008542; P:visual learning; IMP:FlyBase. 

Interpro

 IPR014183; ADH_3.
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS