UniProt Accession

 ACTC_HUMAN; P68032; P04270 

Genbank Protein ID

 J00073; J00070; J00071; J00072; CR541795; BC009978 

Genbank Nucleotide ID

 AAB59619.1; AAB59619.1; AAB59619.1; AAB59619.1; CAG46594.1; AAH09978.1 

Protein Name

 Actin, alpha cardiac muscle 1 

Protein Synonyms/Alias

 Alpha-cardiac actin 

Gene Name

 ACTC1 

Gene Synonyms/Alias

 ACTC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	KRGILTLKYPIEHGI	ubiquitination	[1, 2, 3, 4]
86	TNWDDMEKIWHHTFY	ubiquitination	[2, 4, 5]
115	TEAPLNPKANREKMT	ubiquitination	[1]
293	KCDIDIRKDLYANNV	ubiquitination	[2, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 3 3 N-acetylaspartate (By similarity).
 MOD_RES 46 46 Methionine sulfoxide (By similarity).
 MOD_RES 55 55 Phosphotyrosine (By similarity).
 MOD_RES 75 75 Tele-methylhistidine (By similarity).
 MOD_RES 93 93 Phosphotyrosine (By similarity).
 MOD_RES 242 242 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; ATP-binding; Atrial septal defect; Cardiomyopathy; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Methylation; Muscle protein; Nucleotide-binding; Oxidation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0042643; C:actomyosin, actin part; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0031674; C:I band; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0016887; F:ATPase activity; IDA:UniProtKB.
 GO:0017022; F:myosin binding; IDA:BHF-UCL.
 GO:0006915; P:apoptotic process; ISS:UniProtKB.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0055008; P:cardiac muscle tissue morphogenesis; ISS:UniProtKB.
 GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
 GO:0060047; P:heart contraction; IMP:UniProtKB.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0030240; P:skeletal muscle thin filament assembly; ISS:UniProtKB. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.