| Tag | Content |
|---|
| CPLM ID | CPLM-001670 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitogen-activated protein kinase kinase kinase kinase 4 |
Protein Synonyms/Alias | HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase |
Gene Name | MAP4K4 |
Gene Synonyms/Alias | HGK; KIAA0687; NIK |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 931 | SSTLQKHKSSSSFTP | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. |
Sequence Annotation | DOMAIN 25 289 Protein kinase.
DOMAIN 926 1213 CNH.
NP_BIND 31 39 ATP (By similarity).
REGION 858 1212 Mediates interaction with RAP2A.
ACT_SITE 153 153 Proton acceptor (By similarity).
BINDING 54 54 ATP (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 5 5 Phosphoserine.
MOD_RES 629 629 Phosphoserine.
MOD_RES 631 631 Phosphoserine.
MOD_RES 639 639 Phosphoserine.
MOD_RES 644 644 Phosphoserine.
MOD_RES 712 712 Phosphoserine.
MOD_RES 800 800 Phosphoserine.
MOD_RES 801 801 Phosphoserine (By similarity).
MOD_RES 805 805 Phosphoserine.
MOD_RES 900 900 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1239 AA |
Protein Sequence | MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 120
KGNTLKEDWI AYISREILRG LAHLHIHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 300
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ 360
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR 420
RQQEREQRRR EQEEKRRLEE LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE 480
VLQQQLLQEQ AMLLECRWRE MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP 540
PPQQERSKPS FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS 600
ESFSNGNSES VHPALQRPAE PQVQWSHLAS LKNNVSPVSR SHSFSDPSPK FAHHHLRSQD 660
PCPPSRSEVL SQSSDSKSEA PDPTQKAWSR SDSDEVPPRV PVRTTSRSPV LSRRDSPLQG 720
SGQQNSQAGQ RNSTSIEPRL LWERVEKLVP RPGSGSSSGS SNSGSQPGSH PGSQSGSGER 780
FRVRSSSKSE GSPSQRLENA VKKPEDKKEV FRPLKPAGEV DLTALAKELR AVEDVRPPHK 840
VTDYSSSSEE SGTTDEEDDD VEQEGADEST SGPEDTRAAS SLNLSNGETE SVKTMIVHDD 900
VESEPAMTPS KEGTLIVRQT QSASSTLQKH KSSSSFTPFI DPRLLQISPS SGTTVTSVVG 960
FSCDGMRPEA IRQDPTRKGS VVNVNPTNTR PQSDTPEIRK YKKRFNSEIL CAALWGVNLL 1020
VGTESGLMLL DRSGQGKVYP LINRRRFQQM DVLEGLNVLV TISGKKDKLR VYYLSWLRNK 1080
ILHNDPEVEK KQGWTTVGDL EGCVHYKVVK YERIKFLVIA LKSSVEVYAW APKPYHKFMA 1140
FKSFGELVHK PLLVDLTVEE GQRLKVIYGS CAGFHAVDVD SGSVYDIYLP THIQCSIKPH 1200
AIIILPNTDG MELLVCYEDE GVYVNTYGRI TKDVVLQWGE MPTSVAYIRS NQTMGWGEKA 1260
IEIRSVETGH LDGVFMHKRA QRLKFLCERN DKVFFASVRS GGSSQVYFMT LGRTSLLSW 1319 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0005524; F:ATP binding; IDA:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. GO:0005083; F:small GTPase regulator activity; IEA:InterPro. GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB. GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB. GO:0006950; P:response to stress; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |