UniProt Accession

 KIME_HUMAN; Q03426 

Genbank Protein ID

 M88468; X75311; X75311; AF217535; AF217528; AF217529; AF217530; AF217531; AF217532; AF217533; AF217534; BC016140 

Genbank Nucleotide ID

 AAB59362.1; CAA53060.1; CAA53059.1; AAF82407.1; AAF82407.1; AAF82407.1; AAF82407.1; AAF82407.1; AAF82407.1; AAF82407.1; AAF82407.1; AAH16140.1 

Protein Name

 Mevalonate kinase 

Protein Synonyms/Alias

 MK 

Gene Name

 MVK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	SLPNIGIKRAWDVAR	ubiquitination	[1]
238	QILLTNTKVPRNTRA	ubiquitination	[1]
256	GVRNRLLKFPEIVAP	sumoylation	[2]
345	GCGITLLKPGLEQPE	sumoylation	[2]
345	GCGITLLKPGLEQPE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries.
 Wang L, Gulappa T, Menon KM.
 Biochim Biophys Acta. 2010 May;1803(5):591-7. [PMID: 20167237] 

Functional Description

 May be a regulatory site in cholesterol biosynthetic pathway. 

Sequence Annotation

 NP_BIND 138 148 ATP (By similarity).
 BINDING 55 55 ATP (By similarity).
 BINDING 135 135 ATP (By similarity).  

Keyword

 3D-structure; ATP-binding; Cataract; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Cytoplasm; Disease mutation; Kinase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Polymorphism; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004496; F:mevalonate kinase activity; IDA:UniProtKB.
 GO:0006695; P:cholesterol biosynthetic process; IDA:UniProtKB.
 GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
 GO:0008299; P:isoprenoid biosynthetic process; IDA:UniProtKB.
 GO:0050728; P:negative regulation of inflammatory response; IMP:BHF-UCL. 

Interpro

 IPR013750; GHMP_kinase_C_dom.
 IPR006204; GHMP_kinase_N_dom.
 IPR006203; GHMP_knse_ATP-bd_CS.
 IPR006205; Mev_gal_kin.
 IPR006206; Mevalonate/galactokinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 

Pfam

 PF08544; GHMP_kinases_C
 PF00288; GHMP_kinases_N 

SMART

  

PROSITE

 PS00627; GHMP_KINASES_ATP 

PRINTS

 PR00959; MEVGALKINASE.