UniProt Accession

 SBDS_RAT; Q5RK30 

Genbank Protein ID

 BC086335 

Genbank Nucleotide ID

 AAH86335.1 

Protein Name

 Ribosome maturation protein SBDS 

Protein Synonyms/Alias

 Shwachman-Bodian-Diamond syndrome protein homolog 

Gene Name

 Sbds 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
90	ICKQILTKGEVQVSD	acetylation	[1]
184	LLPVNEGKKLKEKLK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 250 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0000922; C:spindle pole; ISS:UniProtKB.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0003723; F:RNA binding; IBA:RefGenome.
 GO:0008283; P:cell proliferation; ISS:UniProtKB.
 GO:0001833; P:inner cell mass cell proliferation; IEA:Compara.
 GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
 GO:0042273; P:ribosomal large subunit biogenesis; IBA:RefGenome.
 GO:0006364; P:rRNA processing; IBA:RefGenome. 

Interpro

 IPR018978; Ribosome_mat_SBDS_C.
 IPR018023; Ribosome_mat_SBDS_CS.
 IPR019783; Ribosome_mat_SBDS_N.
 IPR002140; Ribosome_maturation_pr_SBDS. 

Pfam

 PF01172; SBDS
 PF09377; SBDS_C 

SMART

  

PROSITE

 PS01267; UPF0023 

PRINTS