CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041374
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal transducer and activator of transcription 6 
Protein Synonyms/Alias
  
Gene Name
 STAT6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16AERVPWEKMCETLNLubiquitination[1]
70VSWSQFNKEILLGRGubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 154 AA 
Protein Sequence
MDRVPFVVAE RVPWEKMCET LNLKFMAEVG TNRGLLPEHF LFLAQKIFND NSLSMEAFQH 60
RSVSWSQFNK EILLGRGFTF WQWFDGVLDL TKRCLRSYWS DRLIIGFISK QYVTSLLLNE 120
PDGTFLLRFS DSEIGGITIA HVIRGQDGSP QIEN 154 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0060443; P:mammary gland morphogenesis; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0002829; P:negative regulation of type 2 immune response; IEA:Compara.
 GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0002296; P:T-helper 1 cell lineage commitment; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd. 
Pfam
 PF00017; SH2
 PF02864; STAT_bind 
SMART
  
PROSITE
 PS50001; SH2 
PRINTS