| Tag | Content |
|---|
| CPLM ID | CPLM-018695 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TOM1-like protein 1 |
Protein Synonyms/Alias | Src-activating and signaling molecule protein; Target of Myb-like protein 1 |
Gene Name | Tom1l1 |
Gene Synonyms/Alias | Srcasm |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MAFGKSHRDPYA | ubiquitination | [1] | | 148 | EVYLDLLKKGVQFPP | ubiquitination | [1] | | 190 | LSSIIAPKNPTISLV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. |
Sequence Annotation | DOMAIN 22 154 VHS.
DOMAIN 199 287 GAT.
REGION 392 395 Interaction with GRB2.
REGION 441 444 Interaction with PIK3R1.
MOTIF 420 424 SH3-binding.
MOTIF 457 460 SH2-binding.
MOD_RES 313 313 Phosphoserine (By similarity).
MOD_RES 320 320 Phosphoserine (By similarity).
MOD_RES 457 457 Phosphotyrosine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; SH3-binding; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 474 AA |
Protein Sequence | MAFGKSHRDP YATSVGHLIE KATFAGVLTE DWGQFLHICD IINTTQDGPK DAVKALKKRI 60
SKNYNHKEIQ LSLSLIDMCV QNCGPSFQSL IVKKEFIKDT LVKLLNPRYT LPLETQNRIL 120
NFIKTWSQGF PGGVDVSEVK EVYLDLLKKG VQFPPSDGEP ETRQEAGQIS PNRPTSVPTA 180
PALSSIIAPK NPTISLVPEQ IGKLHSELDM VKMNVKVMTA ILMENTPGSE NHEDIELLRK 240
LYKTGREMQE RIMDLLVVVE NEDVTMELIQ VNEDLNNAVL GYERFTRNQQ RLLEQKRNRT 300
EATRTSSEPS APSCDLLDLS PIVPVPTPNE GALNSVNAQL SGLSVSSLSP VITNNLYPSL 360
QPQRDLLASE DIEIPTLFPQ RTSQNLASSH TYDNFHSNSV LLQPVSLHTA TAAAAANQRL 420
PPLPSSHPVL KDGDLQPPNY YEVMEFDPLA PTTEAVYEEI DGYHQKEAQS HSDC 474 |
Gene Ontology | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell. GO:0030295; F:protein kinase activator activity; IDA:MGI. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |