UniProt Accession

 GNS_HUMAN; P15586; Q53F05 

Genbank Protein ID

 Z12173; AK223484; AC025262; BC012482 

Genbank Nucleotide ID

 CAA78164.1; BAD97204.1; AAH12482.1 

Protein Name

 N-acetylglucosamine-6-sulfatase 

Protein Synonyms/Alias

 Glucosamine-6-sulfatase; G6S 

Gene Name

 GNS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
125	CSSKSWQKIQEPNTF	ubiquitination	[1, 2]
502	IDPELLGKMNYRLMM	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 METAL 55 55 Calcium (By similarity).
 METAL 56 56 Calcium (By similarity).
 METAL 91 91 Calcium; via 3-oxoalanine (By
 METAL 326 326 Calcium (By similarity).
 METAL 327 327 Calcium (By similarity).
 MOD_RES 91 91 3-oxoalanine (Cys) (By similarity).
 CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 183 183 N-linked (GlcNAc...).
 CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).
 CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
 CARBOHYD 279 279 N-linked (GlcNAc...).
 CARBOHYD 317 317 N-linked (GlcNAc...).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).
 CARBOHYD 387 387 N-linked (GlcNAc...).
 CARBOHYD 405 405 N-linked (GlcNAc...) (Potential).
 CARBOHYD 422 422 N-linked (GlcNAc...).
 CARBOHYD 449 449 N-linked (GlcNAc...) (Potential).
 CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Hydrolase; Lysosome; Metal-binding; Mucopolysaccharidosis; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 552 AA 

Protein Sequence

Gene Ontology

 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008449; F:N-acetylglucosamine-6-sulfatase activity; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0042340; P:keratan sulfate catabolic process; TAS:Reactome. 

Interpro

 IPR017849; Alkaline_Pase-like_a/b/a.
 IPR017850; Alkaline_phosphatase_core.
 IPR012251; GlcNAc_6-SO4ase.
 IPR015981; GlcNAc_6-SO4ase_euk.
 IPR000917; Sulfatase.
 IPR024607; Sulfatase_CS. 

Pfam

 PF00884; Sulfatase 

SMART

  

PROSITE

 PS00523; SULFATASE_1
 PS00149; SULFATASE_2 

PRINTS