| Tag | Content |
|---|
| CPLM ID | CPLM-002247 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Delta-aminolevulinic acid dehydratase |
Protein Synonyms/Alias | ALADH; Porphobilinogen synthase |
Gene Name | HEM2 |
Gene Synonyms/Alias | YGL040C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 170 | AVAVNYAKAGAHCVA | ubiquitination | [1] | | 263 | GADGIIVKPSTFYLD | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. |
Sequence Annotation | ACT_SITE 210 210 Schiff-base intermediate with substrate.
ACT_SITE 263 263 Schiff-base intermediate with substrate.
METAL 133 133 Zinc; catalytic.
METAL 135 135 Zinc; catalytic.
METAL 143 143 Zinc; catalytic.
BINDING 220 220 Substrate 1.
BINDING 232 232 Substrate 1.
BINDING 290 290 Substrate 2.
BINDING 329 329 Substrate 2.
MOD_RES 254 254 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; Heme biosynthesis; Lyase; Metal-binding; Phosphoprotein; Porphyrin biosynthesis; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 342 AA |
Protein Sequence | MHTAEFLETE PTEISSVLAG GYNHPLLRQW QSERQLTKNM LIFPLFISDN PDDFTEIDSL 60
PNINRIGVNR LKDYLKPLVA KGLRSVILFG VPLIPGTKDP VGTAADDPAG PVIQGIKFIR 120
EYFPELYIIC DVCLCEYTSH GHCGVLYDDG TINRERSVSR LAAVAVNYAK AGAHCVAPSD 180
MIDGRIRDIK RGLINANLAH KTFVLSYAAK FSGNLYGPFR DAACSAPSNG DRKCYQLPPA 240
GRGLARRALE RDMSEGADGI IVKPSTFYLD IMRDASEICK DLPICAYHVS GEYAMLHAAA 300
EKGVVDLKTI AFESHQGFLR AGARLIITYL APEFLDWLDE EN 342 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0032791; F:lead ion binding; ISS:UniProtKB. GO:0004655; F:porphobilinogen synthase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; ISS:UniProtKB. GO:0006783; P:heme biosynthetic process; ISS:UniProtKB. GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |