UniProt Accession

 MTCH2_HUMAN; Q9Y6C9; B2R7L8 

Genbank Protein ID

 AY380792; AF176008; AF085361; AK313032; CH471064; BC000875 

Genbank Nucleotide ID

 AAQ88168.1; AAD52646.1; AAD40196.1; BAG35865.1; EAW67892.1; AAH00875.1 

Protein Name

 Mitochondrial carrier homolog 2 

Protein Synonyms/Alias

 Met-induced mitochondrial protein 

Gene Name

 MTCH2 

Gene Synonyms/Alias

 MIMP; HSPC032 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	LGTVVHGKVLQHYQE	ubiquitination	[1, 2, 3]
100	QHYQESDKGEELGPG	ubiquitination	[1, 2, 3, 4, 5]
111	LGPGNVQKEVSSSFD	ubiquitination	[1, 2, 3, 4, 5]
122	SSFDHVIKETTREMI	ubiquitination	[2, 4, 5, 6]
293	FRKVPFGKTYCCDLK	ubiquitination	[2, 6]
300	KTYCCDLKMLI****	ubiquitination	[2, 6]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 The substrate transported is not yet known. Induces mitochondrial depolarization. 

Sequence Annotation

 REPEAT 2 98 Solcar 1.
 REPEAT 118 206 Solcar 2.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 158 158 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS