CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027904
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BM-010 
Protein Synonyms/Alias
 Eukaryotic initiation factor 4A-II; Eukaryotic translation initiation factor 4A, isoform 2, isoform CRA_b 
Gene Name
 EIF4A2 
Gene Synonyms/Alias
 hCG_1784041 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52NVRNEMQKLQAEAPHubiquitination[1]
99EMLSRGFKDQIYEIFubiquitination[1]
215LHGDMDQKERDVIMRubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Initiation factor; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MLTVLRSLPL FSRELLFPVL KIQKVILALG DYMGATCHAC IGGTNVRNEM QKLQAEAPHI 60
VVGTPGRVFD MLNRRYLSPK WIKMFVLDEA DEMLSRGFKD QIYEIFQKLN TSIQVVLLSA 120
TMPTDVLEVT KKFMRDPIRI LVKKEELTLE GIKQFYINVE REEWKLDTLC DLYETLTITQ 180
AVIFLNTRRK VDWLTEKMHA RDFTVSALHG DMDQKERDVI MREFRSGSSR VLITTDLLAR 240
GIDVQQVSLV INYDLPTNRE NYIHRIGRGG RFGRKGVAIN FVTEEDKRIL RDIETFYNTT 300
VEEMPMNVAD LI 312 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS