CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030973
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transducer and activator of transcription 2 
Protein Synonyms/Alias
 cDNA FLJ59331, highly similar to Signal transducer and activator of transcription 2 
Gene Name
 STAT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
157AMMEKLVKSISQLKDubiquitination[1]
235LPKLEEWKAQQQKACubiquitination[1]
291YQDDPLTKGVDLRNAubiquitination[1]
371PQLQGFRKFNILTSNubiquitination[1]
380NILTSNQKTLTPEKGubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 460 AA 
Protein Sequence
MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG SDDSKATMLF 60
FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQDPTQL AEMIFNLLLE EKRILIQAQR 120
AQLEQGEPVL ETPVESQQHE IESRILDLRA MMEKLVKSIS QLKDQQDVFC FRYKIQAKGK 180
TPSLDPHQTK EQKILQETLN ELDKRRKEVL DASKALLGRL TTLIELLLPK LEEWKAQQQK 240
ACIRAPIDHG LEQLETWFTA GAKLLFHLRQ LLKELKGLSC LVSYQDDPLT KGVDLRNAQV 300
TELLQRLLHR AFVVETQPCM PQTPHRPLIL KTGSKFTVRT RLLVRLQEGN ESLTVEVSID 360
RNPPQLQGFR KFNILTSNQK TLTPEKGQSQ GLIWDFGYLT LVEQRSGGSG KGSNKGPLGV 420
TEELHIISFT VKYTYQGLKQ ELKVSENGGQ GERKQLWKKA 460 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro. 
Interpro
 IPR008967; p53-like_TF_DNA-bd.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 
Pfam
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 
SMART
 SM00964; STAT_int 
PROSITE
  
PRINTS