CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018329
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SPRY domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 SPRYD4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95HYWEVTVKRSQQFRIacetylation[1]
130VFTYAQRKWYTMLANacetylation[1]
139YTMLANEKAPVEGIGacetylation[2, 3]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
 DOMAIN 12 206 B30.2/SPRY.
 MOD_RES 130 130 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MALLFARSLR LCRWGAKRLG VASTEAQRGV SFKLEEKTAH SSLALFRDDM GVKYGLVGLE 60
PTKVALNVER FREWAVVLAD TAVTSGRHYW EVTVKRSQQF RIGVADVDMS RDSCIGVDDR 120
SWVFTYAQRK WYTMLANEKA PVEGIGQPEK VGLLLEYEAQ KLSLVDVSQV SVVHTLQTDF 180
RGPVVPAFAL WDGELLTHSG LEVPEGL 207 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
  
PROSITE
 PS50188; B302_SPRY 
PRINTS
 PR01407; BUTYPHLNCDUF.