UniProt Accession

 MED11_HUMAN; Q9P086; Q6NS89 

Genbank Protein ID

 AF161414; CH471108; BC070377 

Genbank Nucleotide ID

 AAF28974.1; EAW90417.1; AAH70377.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 11 

Protein Synonyms/Alias

 Mediator complex subunit 11 

Gene Name

 MED11 

Gene Synonyms/Alias

 HSPC296 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	RVDYARLKLSDVART	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 

Sequence Annotation

  

Keyword

 Activator; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; IDA:MGI.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro. 

Interpro

 IPR019404; Mediator_Med11. 

Pfam

 PF10280; Med11 

SMART

  

PROSITE

  

PRINTS