UniProt Accession

 TBCB_MOUSE; Q9D1E6; Q9CWR6; Q9DCZ6 

Genbank Protein ID

 AK002316; AK003655; AK010438; BC010684 

Genbank Nucleotide ID

 BAB22009.1; BAB22918.2; BAB26939.1; AAH10684.1 

Protein Name

 Tubulin-folding cofactor B 

Protein Synonyms/Alias

 Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B 

Gene Name

 Tbcb 

Gene Synonyms/Alias

 Ckap1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
103	GEYEDVSKVEKYEIS	ubiquitination	[1]
106	EDVSKVEKYEISPEA	ubiquitination	[1]
129	RSFMKRSKLGPYNEE	ubiquitination	[1]
153	AQRLSEEKAQASAIS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. 

Sequence Annotation

 DOMAIN 183 225 CAP-Gly.
 MOD_RES 65 65 Phosphoserine; by PAK1 (By similarity).
 MOD_RES 98 98 Phosphotyrosine.
 MOD_RES 110 110 Phosphoserine (By similarity).
 MOD_RES 128 128 Phosphoserine; by PAK1 (By similarity).
 MOD_RES 219 219 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW. 

Interpro

 IPR000938; CAP-Gly_domain. 

Pfam

 PF01302; CAP_GLY 

SMART

 SM01052; CAP_GLY 

PROSITE

 PS00845; CAP_GLY_1
 PS50245; CAP_GLY_2 

PRINTS