UniProt Accession

 C9IZS4_HUMAN; C9IZS4 

Genbank Protein ID

 AC016727 

Genbank Nucleotide ID

  

Protein Name

 Exportin-1 

Protein Synonyms/Alias

 Uncharacterized protein 

Gene Name

 XPO1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	QEVLTHLKEHPDAWT	ubiquitination	[1]
88	QILENVIKTRWKIL*	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 94 AA 

Protein Sequence

Gene Ontology

 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006611; P:protein export from nucleus; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IEA:Compara.
 GO:0010824; P:regulation of centrosome duplication; IEA:Compara.
 GO:0042176; P:regulation of protein catabolic process; IEA:Compara.
 GO:0046825; P:regulation of protein export from nucleus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001494; Importin-beta_N. 

Pfam

 PF03810; IBN_N 

SMART

  

PROSITE

 PS50166; IMPORTIN_B_NT 

PRINTS