CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041284
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat domain 55, isoform CRA_b 
Protein Synonyms/Alias
 WD repeat-containing protein 55 
Gene Name
 WDR55 
Gene Synonyms/Alias
 hCG_1782892 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
159SGHDQRLKFWDMAQLubiquitination[1, 2, 3]
190PLRALSSKTWSTDDFubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 222 AA 
Protein Sequence
MDMRQHEEYI ADMALDPAKK LLLTASGDGC LGIFNIKRRR FELLSEPQSG DLTSVTLMKW 60
GKKVACGSSE GTIYLFNWNG FGATSDRFAL RAESIDCMVP VTESLLCTGS TDGVIRAVNI 120
LPNRVVGSVG QHTGEPVEEL ALSHCGRFLA SSGHDQRLKF WDMAQLRAVV VDDYRRRKKK 180
GGPLRALSSK TWSTDDFFAG LREEGEDSMA QEEKEETGDD SD 222 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:Compara. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS