CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040478
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inosine-5'-monophosphate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Impdh1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
249APAGVTLKEANEILQubiquitination[1]
262LQRSKKGKLPIVNDQubiquitination[1]
296LASKDSHKQLLCGAAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 385 385 Thioimidate intermediate (By similarity).  
Keyword
 Complete proteome; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purine biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
ERTGALIAYA GSGASTRRGS RRLELRPPHG MEEPLSPPPE SGLLSPLLQG GGAAAAPEPG 60
ARQHPGHETA AQRYSARLLQ AGYEPESDFL ILPGFIDFIA DEVDLTSALT RKITLKTPLI 120
SSPMDTVTEA DMAIAMALMG GIGFIHHNCT PEFQANEVRK VKKFEQGFIT DPVVLSPSHT 180
VGDVLEAKIQ HGFSGIPITA TGTMGSKLVG IVTSRDIDFL AEKDHTTLLS EVMTPRVELV 240
VAPAGVTLKE ANEILQRSKK GKLPIVNDQD ELVAIIARTD LKKNRDYPLA SKDSHKQLLC 300
GAAVGTREDD KYRLDLLTQA GADVIVLDSS QGNSVYQIAM VHYIKQKYPH LQVIGGNVVT 360
AAQAKNLIDA GVDGLRVGMG CGSICITQEV MACGRPQGTA VYKVAEYARR FGVPVIADGG 420
IQTVGHVVKA LALGASTVMM GSLLAATTEA PGEYFFSDGV RLKKYRGMGS LDAMEKSSSS 480
QKRYFSEGDK VKIAQGVSGS IQDKGSIQKF VPYLIAGIQH GCQDIGAQSL SVLRSMMYSG 540
ELKFEKRTMS AQIEGGVHGL HSYEKRLY 568 
Gene Ontology
 GO:0003938; F:IMP dehydrogenase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006177; P:GMP biosynthetic process; IEA:UniProtKB-KW.
 GO:0046651; P:lymphocyte proliferation; IMP:MGI.
 GO:0006164; P:purine nucleotide biosynthetic process; IMP:MGI. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR000644; Cysta_beta_synth_core.
 IPR005990; IMP_DH.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 
Pfam
 PF00571; CBS
 PF00478; IMPDH 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS
 PS00487; IMP_DH_GMP_RED 
PRINTS