UniProt Accession

 TPM3_MOUSE; P21107; Q09021; Q60606; Q80SW6; Q9EPW3 

Genbank Protein ID

 X53753; U04541; AF317223; AK088111; AK088902; X72633 

Genbank Nucleotide ID

 CAA37782.1; AAA03725.1; AAG38596.1; BAC40150.1; BAC40643.1; CAA51209.1 

Protein Name

 Tropomyosin alpha-3 chain 

Protein Synonyms/Alias

 Gamma-tropomyosin; Tropomyosin-3 

Gene Name

 Tpm3 

Gene Synonyms/Alias

 Tpm-5; Tpm5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	TTTIEAVKRKIQVLQ	ubiquitination	[1]
13	TIEAVKRKIQVLQQQ	ubiquitination	[1]
181	AEEKYSQKEDKYEEE	acetylation	[2]
184	KYSQKEDKYEEEIKI	acetylation	[2]
223	TIDDLEDKLKCTKEE	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. 

Sequence Annotation

 MOD_RES 284 284 Phosphoserine.  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0030426; C:growth cone; IDA:MGI.
 GO:0002102; C:podosome; IDA:MGI.
 GO:0001725; C:stress fiber; ISO:MGI. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.