CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015560
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 13D 
Protein Synonyms/Alias
  
Gene Name
 ANKRD13D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
27GIPELLNKLRQAPDFubiquitination[1, 2]
51SWVPLVSKMCPSDVYubiquitination[1, 2, 3]
159NVAFERNKCGIWGWRubiquitination[1, 4]
169IWGWRSEKMETVSGYubiquitination[1]
209KSRSKAGKTPFQSFLubiquitination[5]
268RPIEMSSKVQRFKATubiquitination[1]
322LPPGFPVKIEIPLFHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
 REPEAT 395 414 UIM 1.
 REPEAT 441 460 UIM 2.
 REPEAT 477 496 UIM 3.
 MOD_RES 465 465 Phosphoserine.
 MOD_RES 469 469 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 518 AA 
Protein Sequence
MVQLVLQYRD YQRATQRLAG IPELLNKLRQ APDFYVEMKW EFTSWVPLVS KMCPSDVYRV 60
WKRGESLRVD TSLLGFEHMT WQRGRRSFIF KGQEAGALVM EVDHDRQVVH VETLGLTLQE 120
PETLLAAMRP SEEHVASRLT SPIVSTHLDT RNVAFERNKC GIWGWRSEKM ETVSGYEAKV 180
YSATNVELVT RTRTEHLSDQ DKSRSKAGKT PFQSFLGMAQ QHSSHTGAPV QQAASPTNPT 240
AISPEEYFDP NFSLESRNIG RPIEMSSKVQ RFKATLWLSE EHPLSLGDQV TPIIDLMAIS 300
NAHFAKLRDF ITLRLPPGFP VKIEIPLFHV LNARITFSNL CGCDEPLSSV WVPAPSSAVA 360
ASGNPFPCEV DPTVFEVPNG YSVLGMERNE PLRDEDDDLL QFAIQQSLLE AGTEAEQVTV 420
WEALTNTRPG ARPPPQATVY EEQLQLERAL QESLQLSTEP RGPGSPPRTP PAPGPPSFEE 480
QLRLALELSS REQEERERRG QQEEEDLQRI LQLSLTEH 518 
Gene Ontology
  
Interpro
 IPR021832; ANKRD13.
 IPR003903; Ubiquitin-int_motif. 
Pfam
 PF11904; GPCR_chapero_1 
SMART
 SM00726; UIM 
PROSITE
 PS50330; UIM 
PRINTS