UniProt Accession

 PLCD1_HUMAN; P51178; B3KR14; Q86VN8 

Genbank Protein ID

 U09117; AK090774; AC144536; CH471055; BC050382 

Genbank Nucleotide ID

 AAA73567.1; BAG52226.1; EAW64507.1; AAH50382.2 

Protein Name

 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 

Protein Synonyms/Alias

 Phosphoinositide phospholipase C-delta-1; Phospholipase C-III; PLC-III; Phospholipase C-delta-1; PLC-delta-1 

Gene Name

 PLCD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	YKLQEDCKTIWQESR	ubiquitination	[1]
86	HRTEGLEKFARDVPE	ubiquitination	[1]
102	RCFSIVFKDQRNTLD	ubiquitination	[1]
163	KDNKMSFKELQNFLK	ubiquitination	[1, 2, 3]
712	EDYDASSKNDFIGQS	ubiquitination	[2, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. 

Sequence Annotation

 DOMAIN 21 130 PH.
 DOMAIN 140 175 EF-hand 1.
 DOMAIN 176 211 EF-hand 2.
 DOMAIN 296 440 PI-PLC X-box.
 DOMAIN 492 609 PI-PLC Y-box.
 DOMAIN 616 720 C2.
 REGION 30 57 Substrate binding (By similarity).
 ACT_SITE 311 311 By similarity.
 ACT_SITE 356 356 By similarity.
 METAL 312 312 Calcium 1; catalytic (By similarity).
 METAL 341 341 Calcium 1; catalytic (By similarity).
 METAL 343 343 Calcium 1; catalytic (By similarity).
 METAL 390 390 Calcium 1; catalytic (By similarity).
 METAL 651 651 Calcium 2; via carbonyl oxygen (By
 METAL 653 653 Calcium 2 (By similarity).
 METAL 677 677 Calcium 2 (By similarity).
 METAL 706 706 Calcium 3 (By similarity).
 METAL 707 707 Calcium 3; via carbonyl oxygen (By
 METAL 708 708 Calcium 3 (By similarity).
 BINDING 438 438 Substrate (By similarity).
 BINDING 440 440 Substrate (By similarity).
 BINDING 522 522 Substrate (By similarity).
 BINDING 549 549 Substrate (By similarity).  

Keyword

 Alternative splicing; Calcium; Complete proteome; Disease mutation; Hydrolase; Lipid degradation; Lipid metabolism; Metal-binding; Polymorphism; Reference proteome; Repeat; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 756 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0060716; P:labyrinthine layer blood vessel development; IEA:Compara.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0006644; P:phospholipid metabolic process; TAS:ProtInc.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara. 

Interpro

 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR011993; PH_like_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR001849; Pleckstrin_homology.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 

Pfam

 PF00168; C2
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y 

SMART

 SM00239; C2
 SM00054; EFh
 SM00233; PH
 SM00148; PLCXc
 SM00149; PLCYc 

PROSITE

 PS50004; C2
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50003; PH_DOMAIN
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 

PRINTS

 PR00390; PHPHLIPASEC.