CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021690
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Magnesium transporter MRS2 homolog, mitochondrial 
Protein Synonyms/Alias
 MRS2-like protein 
Gene Name
 MRS2 
Gene Synonyms/Alias
 HPT; MRS2L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90APVFTVTKFDKQGNVacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
 Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Ion transport; Magnesium; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 443 AA 
Protein Sequence
MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL 60
RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF 120
QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY 180
PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS 240
LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY 300
RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG 360
MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMMAS LPKKTLLADR 420
SMELKNSLRL DGLGSGRSIL TNR 443 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro. 
Interpro
 IPR026573; MRS2/LPE10. 
Pfam
  
SMART
  
PROSITE
  
PRINTS