UniProt Accession

 RPP40_HUMAN; O75818; Q5VX97; Q8WVK8 

Genbank Protein ID

 AL359643; BC017871; U94317 

Genbank Nucleotide ID

 CAH73740.1; AAH17871.1; AAC24114.1 

Protein Name

 Ribonuclease P protein subunit p40 

Protein Synonyms/Alias

 RNaseP protein p40; RNase P subunit 1 

Gene Name

 RPP40 

Gene Synonyms/Alias

 RNASEP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	EFISTFIKKGSCYAL	ubiquitination	[1]
121	KLILSLDKDTYEETG	ubiquitination	[2]
208	QIQEHQPKVALSTLR	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Nucleus; Polymorphism; Reference proteome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0005655; C:nucleolar ribonuclease P complex; TAS:ProtInc.
 GO:0004526; F:ribonuclease P activity; TAS:ProtInc.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR013893; RNase_P_Rpp40. 

Pfam

 PF08584; Ribonuc_P_40 

SMART

  

PROSITE

  

PRINTS