UniProt Accession

 FOSL2_HUMAN; P15408; B2RD58; B3KP27; B4DYV4; Q6FG46 

Genbank Protein ID

 X16706; AK055579; AK302622; AK315415; BX647822; CR542262; AC104695; CH471053; CH471053; BC022791 

Genbank Nucleotide ID

 CAA34678.1; BAG51539.1; BAG63866.1; BAG37805.1; CAG47058.1; AAY14908.1; EAX00538.1; EAX00539.1; AAH22791.1 

Protein Name

 Fos-related antigen 2 

Protein Synonyms/Alias

 FRA-2 

Gene Name

 FOSL2 

Gene Synonyms/Alias

 FRA2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
104	LPRPGVIKTIGTTVG	ubiquitination	[1]
222	SVGAVVVKQEPLEED	sumoylation	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634] 

Functional Description

 Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). 

Sequence Annotation

 DOMAIN 124 187 bZIP.
 REGION 126 128 Basic motif (By similarity).
 REGION 129 136 Leucine-zipper (By similarity).
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 200 200 Phosphoserine.
 MOD_RES 211 211 Phosphoserine.
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 320 320 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008219; P:cell death; TAS:ProtInc.
 GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR000837; Leuzip_Fos. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS

 PR00042; LEUZIPPRFOS.