UniProt Accession

 RAB3I_HUMAN; Q96QF0; B7WPJ6; Q6PCE4; Q96A24; Q96QE6; Q96QE7; Q96QE8; Q96QE9; Q96QF1; Q9H673 

Genbank Protein ID

 AJ312896; AJ312897; AJ312898; AJ312899; AJ312900; AJ312901; AK026201; AK027566; AK027671; AC025263; BC015548; BC059358 

Genbank Nucleotide ID

 CAC59835.1; CAC59836.1; CAC59837.1; CAC59838.1; CAC59839.1; CAC59840.1; BAB15391.1; BAB55202.1; BAB55283.1; AAH15548.1; AAH59358.1 

Protein Name

 Rab-3A-interacting protein 

Protein Synonyms/Alias

 Rab3A-interacting protein; Rabin-3; SSX2-interacting protein 

Gene Name

 RAB3IP 

Gene Synonyms/Alias

 RABIN8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
325	YNEFRLWKDEPTMDR	ubiquitination	[1]
383	LQPIRFVKASAVECG	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. 

Sequence Annotation

 MOD_RES 163 163 Phosphoserine.
 MOD_RES 265 265 Phosphothreonine (By similarity).
 MOD_RES 288 288 Phosphoserine (By similarity).
 MOD_RES 290 290 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Guanine-nucleotide releasing factor; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 476 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:BHF-UCL.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; TAS:BHF-UCL.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
 GO:0042384; P:cilium assembly; IMP:BHF-UCL.
 GO:0006893; P:Golgi to plasma membrane transport; TAS:BHF-UCL.
 GO:0033365; P:protein localization to organelle; IMP:BHF-UCL.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR009449; Sec2p. 

Pfam

 PF06428; Sec2p 

SMART

  

PROSITE

  

PRINTS