UniProt Accession

 KMO_RAT; O88867 

Genbank Protein ID

 AF056031; BC088142 

Genbank Nucleotide ID

 AAC62614.1; AAH88142.1 

Protein Name

 Kynurenine 3-monooxygenase 

Protein Synonyms/Alias

 Kynurenine 3-hydroxylase 

Gene Name

 Kmo 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
67	YRGRQALKAVGLEDQ	acetylation	[1]
78	LEDQIVSKGVPMKAR	acetylation	[1]
102	SAIPYGNKSQYILSI	acetylation	[1]
113	ILSISREKLNKDLLT	acetylation	[1]
129	VESYPNAKVHFGHKL	acetylation	[1]
179	TVRAHLMKKPRFDYS	acetylation	[1]
180	VRAHLMKKPRFDYSQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Monooxygenase; NADP; Oxidoreductase; Pyridine nucleotide biosynthesis; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:HAMAP.
 GO:0004502; F:kynurenine 3-monooxygenase activity; IDA:UniProtKB.
 GO:0016174; F:NAD(P)H oxidase activity; IEA:Compara.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0019674; P:NAD metabolic process; IDA:UniProtKB.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IDA:RGD. 

Interpro

 IPR027545; Kynurenine_monooxygenase.
 IPR002938; mOase_FAD-bd.
 IPR003042; Rng_hydrolase-like. 

Pfam

 PF01494; FAD_binding_3 

SMART

  

PROSITE

  

PRINTS

 PR00420; RNGMNOXGNASE.