| Tag | Content |
|---|
| CPLM ID | CPLM-012853 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase |
Protein Synonyms/Alias | Asparagine-linked glycosylation protein 11 homolog; Glycolipid 2-alpha-mannosyltransferase |
Gene Name | ALG11 |
Gene Synonyms/Alias | GT8 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 295 | LDIPLHEKKMTPGHL | ubiquitination | [1] | | 296 | DIPLHEKKMTPGHLL | ubiquitination | [1] | | 329 | FAKLLNKKMVESPPS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain. |
Sequence Annotation | CARBOHYD 257 257 N-linked (GlcNAc...) (Potential).
CARBOHYD 273 273 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Congenital disorder of glycosylation; Disease mutation; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 492 AA |
Protein Sequence | MAAGERSWCL CKLLRFFYSL FFPGLIVCGT LCVCLVIVLW GIRLLLQRKK KLVSTSKNGK 60
NQMVIAFFHP YCNAGGGGER VLWCALRALQ KKYPEAVYVV YTGDVNVNGQ QILEGAFRRF 120
NIRLIHPVQF VFLRKRYLVE DSLYPHFTLL GQSLGSIFLG WEALMQCVPD VYIDSMGYAF 180
TLPLFKYIGG CQVGSYVHYP TISTDMLSVV KNQNIGFNNA AFITRNPFLS KVKLIYYYLF 240
AFIYGLVGSC SDVVMVNSSW TLNHILSLWK VGNCTNIVYP PCDVQTFLDI PLHEKKMTPG 300
HLLVSVGQFR PEKNHPLQIR AFAKLLNKKM VESPPSLKLV LIGGCRNKDD ELRVNQLRRL 360
SEDLGVQEYV EFKINIPFDE LKNYLSEATI GLHTMWNEHF GIGVVECMAA GTIILAHNSG 420
GPKLDIVVPH EGDITGFLAE SEEDYAETIA HILSMSAEKR LQIRKSARAS VSRFSDQEFE 480
VTFLSSVEKL FK 492 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004377; F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity; IEA:EC. GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome. GO:0043687; P:post-translational protein modification; TAS:Reactome. GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |