CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016561
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone acetyltransferase KAT6B 
Protein Synonyms/Alias
 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MYST-4; Protein querkopf 
Gene Name
 Kat6b 
Gene Synonyms/Alias
 Myst4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
380PGRGQKTKVSTTPSSacetylation[1, 2]
394SGHAASGKHSSSRLAacetylation[1, 2]
413TRPGATTKTTTSSTYacetylation[2]
856SSRQSSAKVQSKNKYacetylation[2]
860SSAKVQSKNKYLHSPacetylation[2]
919TSPPRLTKPQSVSIKacetylation[2]
934RKRPFVVKKKRGRKRacetylation[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). Involved in cerebral cortex development. 
Sequence Annotation
 DOMAIN 104 177 H15.
 ZN_FING 214 273 PHD-type 1.
 ZN_FING 270 321 PHD-type 2.
 ZN_FING 567 589 C2HC-type.
 REGION 362 535 Negatively regulates HAT activity (By
 REGION 536 826 Catalytic (By similarity).
 REGION 570 826 Interaction with BRPF1 (By similarity).
 REGION 674 678 Acetyl-CoA binding (By similarity).
 REGION 683 689 Acetyl-CoA binding (By similarity).
 REGION 1359 1872 Interaction with RUNX1 and RUNX2 (By
 ACT_SITE 633 633 By similarity.
 ACT_SITE 675 675 Nucleophile (By similarity).
 BINDING 713 713 Acetyl-CoA (By similarity).
 MOD_RES 633 633 N6-acetyllysine; by autocatalysis (By
 MOD_RES 856 856 N6-acetyllysine (By similarity).
 MOD_RES 860 860 N6-acetyllysine (By similarity).
 MOD_RES 862 862 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Activator; Acyltransferase; Alternative splicing; Chromatin regulator; Complete proteome; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1872 AA 
Protein Sequence
MVKLANPLYT EWILEAVQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ LELSVQDGSV 60
LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK PTKGSKGPPC NDLRNVDWNK LLKRAIEGLE 120
EPNGSSLKNI EKYLRSQSDL TGTTNHPAFQ QRLRLGAKRA VNNGRLLKEG PQYRVNSGSS 180
DGKGAPQYPS AFPSSLPPVS LLPHEKDQPR ADPIPICSFC LGTKESNREK KPEELLSCAD 240
CGSSGHPSCL KFCPELTANV KALRWQCIEC KTCSACRVQG KNADNMLFCD SCDRGFHMEC 300
CDPPLSRMPK GMWICQVCRP KKKGRKLLHE KAAQIKRRYA KPIGRPKNKL KQRLLSVTSD 360
EGSMSAFTGR GSPGRGQKTK VSTTPSSGHA ASGKHSSSRL AVTDPTRPGA TTKTTTSSTY 420
ISASTLKVNK KTKGLIDGLT KFFTPSPDGR RSRGEIIDFS KHYRPRKKVS QKQSCTSHVL 480
ATDTDIKISI KQESADVSLV GNKELVTEED LDVFKQAQEL SWEKIECESG VEDCGRYPSV 540
IEFGKYEIQT WYSSPYPQEY ARLPKLYLCE FCLKYMKSKN ILLRHSKKCG WFHPPANEIY 600
RRKDLSVFEV DGNMSKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVLTKN DEKGCHLVGY 660
FSKEKLCQQK YNVSCIMIMP QHQRQGFGRF LIDFSYLLSR REGQAGSPEK PLSDLGRLSY 720
LAYWKSVILE YLYRHHERHI SIKAISRATG MCPHDIATTL QHLHMIDRRD GRFVIIRREK 780
LILGHMEKLK NCSRPNELDP ESLRWTPMLI SNAVVSEEER EAEKEAERLM EQASCWEKEE 840
QEILSSRVSS RQSSAKVQSK NKYLHSPERR PVAGERGQLL ELSKESSEEE EEEEEEDDEE 900
EEEEEEEESI QTSPPRLTKP QSVSIKRKRP FVVKKKRGRK RRRINSSVTT ETISETTEVL 960
NEPFDNSDEE RPMPQLEPTC EIPVEEGGRK PVLRKAFPHQ PGKKRQTEEE EGEDNHFFKT 1020
AALCRKDVDD DAEHLKEGSK DNPEPLKCRQ VWPKGAKRGL SKWKQSKERK TGFKLNLYTP 1080
PETPMEPEDQ VTIEEQKELS EDKGSPVGME REVTETVDAL LPQEGSRREE TGIPVSPHKS 1140
PGGKVDEEDL IRGEEEGEEE GEEEGEREEQ EEEEEVTTEK DLDGAKSKEN PEPEISMEKE 1200
DPVHLGDHEE DEDEEEEPSH NEDHDADDED DGHMEAANME RGDLPRETFK DALEGQEAFL 1260
DLSIQPSHSN PEVLMNCGVD LTMSCNSEPK ELAGDTGTAP ESDAEPPEEQ TQKQDQKNSD 1320
GVDAELEEGG PAAVEIDSET AQAVQSLTQE NREHDDTFPD CAETQEACRS LQNYTHTDQS 1380
PQIATTLDEC QQSDHSSPVS SVHSHPGQSV RSVNSPSVPA LENSYAQISP DQTAITVPPL 1440
QNMETSPMMD VPSVSDHSQQ VVDSGFSDLG SIESTTENYE NPSSYDSTMG GSICGNGSSQ 1500
NSCSYSSLTS SNLTQNSCAV TQQMSNISGS CSMLQQTSIS SPPTCSVKSP QGCVVERPPS 1560
SSQQLAQCSM AANFTPPMQL ADIPETSNAN IGLYERMGQS DFGAGHYPQP SATFSLAKLQ 1620
QLTNTLIDHS LPYSHSAAVT SYANSASLST PLSNTGLVQL SQSPHSVPGG PQAQATMTPP 1680
PNLTPPPMNL PPPLLQRNMA ASNIGISHSQ RLQTQIASKG HVSMRTKAAS LSPAAATHQS 1740
QIYGRSQTVA MQGPARTLTM QRGMNMSVNL MPAPAYNVNS VNMNMNTLNA MNGYSMSQPM 1800
MNSGYHSNHG YMNQTPQYPM QMQMGMMGSQ PYAQQPMQTP PHANMMYTAP GHHGYMNTGM 1860
SKQSLNGSYM RR 1872 
Gene Ontology
 GO:0070776; C:MOZ/MORF histone acetyltransferase complex; ISS:UniProtKB.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004402; F:histone acetyltransferase activity; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043966; P:histone H3 acetylation; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR005818; Histone_H1/H5.
 IPR002717; MOZ_SAS.
 IPR011991; WHTH_DNA-bd_dom.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00538; Linker_histone
 PF01853; MOZ_SAS
 PF00628; PHD 
SMART
 SM00526; H15
 SM00249; PHD 
PROSITE
 PS51504; H15
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS