UniProt Accession

 UST_HUMAN; Q9Y2C2; B2RCX6 

Genbank Protein ID

 AB020316; AK315320; AL357992; AL359252; AL590485; AL807246; AL359252; AL357992; AL590485; AL807246; AL590485; AL357992; AL359252; AL807246; AL807246; AL357992; AL359252; AL590485; CH471051; BC093668; BC093694 

Genbank Nucleotide ID

 BAA77510.1; BAG37723.1; CAH70738.1; CAH70738.1; CAH70738.1; CAH70738.1; CAH70147.1; CAH70147.1; CAH70147.1; CAH70147.1; CAI17058.1; CAI17058.1; CAI17058.1; CAI17058.1; CAH74028.1; CAH74028.1; CAH74028.1; CAH74028.1; EAW47812.1; AAH93668.1; AAH93694.1 

Protein Name

 Uronyl 2-sulfotransferase 

Protein Synonyms/Alias

  

Gene Name

 UST 

Gene Synonyms/Alias

 DS2ST 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	PPGLGSWKRRVPLLP	ubiquitination	[1, 2]
359	KEQFHLLKRKFGLKS	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. 

Sequence Annotation

 CARBOHYD 84 84 N-linked (GlcNAc...) (Potential).
 CARBOHYD 140 140 N-linked (GlcNAc...) (Potential).
 CARBOHYD 155 155 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 319 319 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0008146; F:sulfotransferase activity; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0030204; P:chondroitin sulfate metabolic process; TAS:Reactome.
 GO:0030208; P:dermatan sulfate biosynthetic process; TAS:Reactome.
 GO:0006477; P:protein sulfation; TAS:ProtInc. 

Interpro

 IPR007734; Heparan_SO4_2-O-STrfase.
 IPR027417; P-loop_NTPase.
 IPR005331; Sulfotransferase. 

Pfam

 PF03567; Sulfotransfer_2 

SMART

  

PROSITE

  

PRINTS